Blog
Introducing Critical Research on Antibody-Drug Conjugates
Control Strategy for Small Molecule Impurities in Antibody-Drug Conjugates Hai H. Gong, Nathan Ihle, and colleagues present valuable insights into controlling impurities in ADCs, a promising class of biopharmaceuticals. With the backing of the International Consortium for Innovation and Quality in Pharmaceutical Development, the team lays out a science-based strategy addressing the challenges of small…Read more
Read MoreUnderstanding Improved Antibody Penetration in Cancer Treatment
Co-administered antibody improves penetration of antibody–dye conjugate into human cancers with implications for antibody–drug conjugates Guolan Lu, Naoki Nishio, and their team address a persistent problem: inadequate penetration of antibody-based cancer treatments into solid tumors. Though antibodies promise a more targeted attack on cancer, delivering them effectively remains a puzzle. Current Obstacles: Penetration…Read more
Read MoreThe Revolution of Antibody-Drug Conjugates in Cancer Treatment
The Dawn of the Antibody–Drug Conjugates Era: How T-DM1 Reinvented the Future of Chemotherapy for Solid Tumors Developing effective cancer treatments with fewer side effects remains a paramount goal in oncology. Paolo Tarantino and Sara M. Tolaney dive deep into a groundbreaking development that has reshaped the future of chemotherapy for solid tumors. …Read more
Read MoreUnlocking the Secrets of ADC Purification: Insights into Ultrafiltration/Diafiltration Techniques in Cancer Treatment Innovations
Introduction to the Research and Authors Antibody−drug conjugates (ADCs) are prominent cancer treatments. The research, “Strategies for UF/DF-Based Impurity Removal in the Post-conjugation Purification of Antibody−Drug Conjugate”, conducted by Lara Fernandez-Cerezo, Melissa Holstein, and their team, seeks to address purification challenges in ADCs. Understanding ADCs and Their Importance ADCs combine a small-molecule drug…Read more
Read MoreSearchlight Workshop: Revolutionizing ADC Development Timelines
Initiating Change with Early Testing   The workshop kicked off with a strong emphasis on early testing in ADC development. They explained that early TOX/PK tests, taken during the conjugation phase, could provide a clearer roadmap for later, pricier GLP tox stages. These proactive measures aim to protect substantial investments, ensuring money is well spent.…Read more
Read MoreInnovative Approach to Advanced Antibody-Drug Conjugates
The Rise of ADCs and Their Current Challenges The recent surge in antibody-drug conjugates (ADC) approvals by the FDA, now totalling eleven, showcases their potential in targeted therapeutics. The majority of these ADCs are produced through cysteine-selective bioconjugation. However, there’s a prevalent challenge with many of these ADCs – they use maleimide functionalized linkers known…Read more
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